The Brain Café is an evening of dialogue at the intersections of neuroscience, medicine, and the arts. It brings together scientists, clinicians, artists, and community members to share their knowledge and experiences. This Brain Café focused on Locked-in Syndrome. It featured the story of Margaret Worthen who suffered a brain Stem stroke when she was 22. Our science presenter was John Simeral Ph.D., a researcher with BrainGate a laboratory at Brown that is developing human/computer interface technology that will someday allow people like Margaret to communicate and control robotic devices.